While it appears that Jeffree actually unfollowed Tati around one month ago—just before the start of his latest documentary series with Shane Dawson—it was the launch of Tati's debut makeup line that alerted their followers to the news.
Not only has Tati publicly supported Jeffree on her channel, uploading stand-alone videos reviewing his concealers, Blue Blood and Jawbreaker collections, but the pair also appeared in a video on Jeffree's channel: Get Ready In My Private Jet.
Jeffree even sent Tati a Louis Vuitton handbag when the pair first started hanging out, and he famously defended her during her feud with James Charles, publicly cutting ties with James in the process.
It doesn't look like Tati will be on the receiving end of any more of Jeffree's gifts however, after he unfollowed her on both Twitter and Instagram.
While neither Jeffree nor Tati have commented publicly, their fans have been speculating online as to what caused the fall out.
Some believe it might be due to Jeffree's upcoming collection with Shane Dawson, after Tati released her own eyeshadow palette one week before theirs.
Another person claimed that Jeffree was blocking everyone on Twitter who supported Tati's palette.
And when Jeffree's former friend, Manny MUA, uploaded a review of Tati's palette, Tati defended herself for supporting him, claiming there were no shady motives and she was "super appreciative" of his support after a "lonely year."
We can only hope that all we be revealed in the next episode of Shane's Beautiful World of Jeffree Star series...
This article originally appeared on Cosmopolitan.com/uk. Minor edits have been made by the Cosmo.ph editors.