ABS-CBN revealed the names of the cast members on October 5, confirming that Joshua will be the male lead in the show. Joshua will be playing a police officer named Brian Samonte Robles.
Zaijan Jaranilla will be playing Darna's sidekick, Ding, while Iza Calzado will portray the role of Leonor Custodio, the mother of Narda and Darna. Leonor is also the "first Darna," a "prime warrior" from Planet Marte.
Other actors part of the cast include Gerard Acao, Tart Carlos, Marvin Yap, Zeppi Borromeo, Yogo Singh, Young JV, LA Santos, Mark Manicad, Levi Ignacio, Joj Agpangan, Simon Ibarra, Richard Quan, Kiko Estrada, and Rio Locsin.
Darna was initially planned to be a feature film directed by Jerrold Tarog, but it was postponed indefinitely in August 2020 due to restrictions brought about by the COVID-19 pandemic. In December 2020, ABS-CBN announced that it would be pushing through with the project as a TV series.
Darna: The TV Series starts taping in November and will be directed by Chito Roño.