The 24-year-old British singer struggled to hold back tears as she accepted the gong with her co-writer Paul Epworth on Sunday night (February 24, 2013).
The Grammy winner, who sang the James Bond theme at the prestigious ceremony earlier in the evening during a special tribute to the British spy franchise, marking her first live performance since giving birth to her son Angelo James in October, said: "Thank you so much. This is amazing."
Listen to "Skyfall's" official music video:
Dressed in a floor-length, embellished black Jenny Packham gown, Adele also paid tribute to her management team.
She then became emotional and quickly thanked her charity worker beau, Simon Konecki, who was her date for the evening and gave her a quick kiss after her name was announced.
She said: "And my man, I love you baby."
Before leaving the stage, the outspoken singer gestured at the star-studded crowd and shouted: "You're all amazing as well."
Other nominees in the category included "Before My Time" from Chasing Ice, "Everybody Needs A Best Friend" from Ted, written by the Oscars host Seth MacFarlane, "Pi's Lullaby" from Life of Pi and "Suddenly" from Les Misérables.
Prior to performing at the event, Adele reportedly underwent special Chinese Qi Gong breathing therapy to help calm her nerves after it was recommended by fellow singer Robbie Williams' wife Ayda Field.
A source previously said: "Adele has suffered with terrible stage fright since she was 16, but now it's worse than ever.
"She knows all eyes are on her after almost a year out of the spotlight, so she needed something to help her with it.
"Ayda was the first person to tell Adele about Belly Breathing, and how it had helped Robbie overcome his performing anxiety in recent years."